Ulusal Romatoloji Dergisi / Journal of Turkish Society for Rheumatology
p-ISSN: 2651-2653
e-ISSN: 2651-2661
Haner Direskeneli
2019 Volume 11
Deomed Yayıncılık
Volume 4, Issue 2, December 2012
Page(s): 39-46
Received: December 27, 2011; Accepted: January 27, 2011; Published online: April 26, 2012
doi:10.2399/raed.12.005; Copyright © 2012 Society for Education and Reserach in Rheumatology (RAED), Turkey
Etiopathogenesis of systemic sclerosis
Süleyman Serdar Koca (E-mail), Metin Özgen, Ahmet Işık
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fırat University, Elazığ, Turkey
Scleroderma (systemic sclerosis; SSc) is a chronic autoimmune/ inflammatory disease leading to by widespread fibrosis of the skin and internal organs. The pathogenesis of SSc is not fully known due to its rarity and clinical heterogeneity. However, it is assumed that its pathogenesis is characterized by the triad of vasculopathy, immune activation and fibrosis, nowadays. Our understanding about the pathogenesis is considerably increased by recent studies. However, etiologic factors triggering the pathogenic process and genetic background are not fully determined. Although it is known how fibroblasts, the main actors of fibrogenesis are activated, it is not adequately understood how the fibroblastic activity is persistent. The automacity and resistance to apoptosis of fibroblasts and the transition of non-fibroblastic cells-to-fibroblastic cells are responsible for the persistence of fibroblastic activity. It is demonstrated that neovascularisation (angiogenesis and vasculogenesis) supplying inflammatory cells and proteolytic enzymes required for restoration of fibrotic tissue is failured in SSc. The cause of deficient neovascularisation remains a mystery.
Keywords: Systemic sclerosis, pathogenesis, fibroblastic activity, neovascularisation
RAED Dergisi / RAED Journal

Türkiye Romatoloji Derneği (TRD) yayın organıdır. Deomed Yayıncılık tarafından yayımlanmaktadır. / Official Publication of the Rheumatology Society of Turkey (TRD). Published by Deomed Publishing. Copyright © 2019, TRD.
Creative Commons License
RAED Dergisi çevrimiçi (online) sürümünde yayımlanan akademik içeriğin kullanım hakları, ilgili içerikte tersi belirtilmediği sürece Deomed Yayıncılık tarafından Creative Commons Attribution-NoCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) lisansı aracılığıyla bedelsiz sunulmaktadır. / Except where otherwise noted, academic content of this online version of the journal by Deomed Publishing is licensed under the terms of Creative Commons Attribution-NoCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) License.