p-ISSN: 1301-4021
e-ISSN: 2147-2548
Editor-in-Chief
Haner Direskeneli
2018 Volume 10
 
 
Deomed Yayıncılık
 
 
 
Volume 4, Issue 2, December 2012
Page(s): 39-46
 
Review
Received: December 27, 2011; Accepted: January 27, 2011; Published online: April 26, 2012
doi:10.2399/raed.12.005; Copyright © 2012 Society for Education and Reserach in Rheumatology (RAED), Turkey
Etiopathogenesis of systemic sclerosis
Süleyman Serdar Koca (E-mail), Metin Özgen, Ahmet Işık
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fırat University, Elazığ, Turkey
Summary
Scleroderma (systemic sclerosis; SSc) is a chronic autoimmune/ inflammatory disease leading to by widespread fibrosis of the skin and internal organs. The pathogenesis of SSc is not fully known due to its rarity and clinical heterogeneity. However, it is assumed that its pathogenesis is characterized by the triad of vasculopathy, immune activation and fibrosis, nowadays. Our understanding about the pathogenesis is considerably increased by recent studies. However, etiologic factors triggering the pathogenic process and genetic background are not fully determined. Although it is known how fibroblasts, the main actors of fibrogenesis are activated, it is not adequately understood how the fibroblastic activity is persistent. The automacity and resistance to apoptosis of fibroblasts and the transition of non-fibroblastic cells-to-fibroblastic cells are responsible for the persistence of fibroblastic activity. It is demonstrated that neovascularisation (angiogenesis and vasculogenesis) supplying inflammatory cells and proteolytic enzymes required for restoration of fibrotic tissue is failured in SSc. The cause of deficient neovascularisation remains a mystery.
Keywords: Systemic sclerosis, pathogenesis, fibroblastic activity, neovascularisation
 
 
Reklam
 
   
RAED Dergisi / RAED Journal

Türkiye Romatoloji Derneği (TRD) yayın organıdır. Deomed Yayıncılık tarafından yayımlanmaktadır. / Official Publication of the Rheumatology Society of Turkey (TRD). Published by Deomed Publishing. Copyright © 2018, TRD.
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