Ulusal Romatoloji Dergisi / Journal of Turkish Society for Rheumatology
p-ISSN: 2651-2653
e-ISSN: 2651-2661
Haner Direskeneli
2019 Volume 11
Deomed Yayıncılık
Volume 4, Issue 2, December 2012
Page(s): 52-58
Received: February 7, 2012; Accepted: February 17, 2012; Published online: August 13, 2012
doi:10.2399/raed.12.009; Copyright © 2012 the Society for Education and Reserach in Rheumatology (RAED), Turkey
Catastrophic antiphospholipid syndrome: diagnostic difficulties and updated diagnostic algorithms
Yelda Deligöz Bildacı1, Doruk Erkan2 (E-mail)
1Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey and 2The Barbara Volcker Center for Women and Rheumatic Disease, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
Catastrophic antiphospholipid syndrome (CAPS) is the most severe form of APS with acute multiple organ involvement and small vessel thrombosis. Early diagnosis and aggressive treatment are crucial for the prognosis of CAPS patients. When CAPS is considered in the differential diagnosis of a patient with multiple organ thromboses, several factors can impede the timely diagnosis. The purpose of this paper is to discuss the diagnostic challenges (i.e., false-positive/negative antiphospholipid antibody [aPL] results, overlap with other thrombotic microangiopathies) as well as the updated diagnostic algorithms for CAPS. Important steps of the diagnostic algorithms include: i) history of APS or persistent aPL-positivity; ii) three or more organ new thromboses developing in less than a week; iii) biopsy diagnosis of microthrombosis; and iv) other explanations for multiple organ thromboses and/or microthrombosis.
Keywords: Antiphospholipid syndrome, catastrophic antiphospholipid syndrome, antiphospholipid antibodies, lupus anticoagulant test, thrombosis
RAED Dergisi / RAED Journal

Türkiye Romatoloji Derneği (TRD) yayın organıdır. Deomed Yayıncılık tarafından yayımlanmaktadır. / Official Publication of the Rheumatology Society of Turkey (TRD). Published by Deomed Publishing. Copyright © 2019, TRD.
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RAED Dergisi çevrimiçi (online) sürümünde yayımlanan akademik içeriğin kullanım hakları, ilgili içerikte tersi belirtilmediği sürece Deomed Yayıncılık tarafından Creative Commons Attribution-NoCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) lisansı aracılığıyla bedelsiz sunulmaktadır. / Except where otherwise noted, academic content of this online version of the journal by Deomed Publishing is licensed under the terms of Creative Commons Attribution-NoCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) License.