p-ISSN: 2651-2653
e-ISSN: 2651-2661
Editor-in-Chief
Haner Direskeneli
2018 Volume 10
 
 
Deomed Yayıncılık
 
 
 
Volume 9, Issue 1-2, December 2017
Page(s): 32-34
 
Review
Received: August 30, 2017; Accepted: September 7, 2017; Published online: November 1, 2017
doi:10.2399/raed.17.14633; Copyright © 2017 Turkish Society for Rheumatology
The role of IL-33 in Behçet's disease
Ayşe Bahar Keleşoğlu Dinçer (E-mail), Müçteba Enes Yayla, Aşkın Ateş
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey
Summary
Behçet's disease (BD) is a chronic multisystemic inflammatory disease characterized with recurrent oral ulcers and accompanying other organ involvements. The etiopathogenesis of the disease is poorly understood. The dysregulation of the innate and adaptive immune systems is the cornerstone of the pathogenesis and various cytokines are found to be increased in BD. One of the most important cytokines involved in the pathogenesis of BD is interleukin-1 (IL-1) which is not only elevated in Behçet patients but also associated with the onset of the disease by single nucleotide polymorphisms. Interleukin-33 (IL-33) is a novel cytokine which belongs to IL-1 cytokine super family. By binding to its receptor ST2, IL-33 acts as a proinflammatory cytokine. Serum IL-33 levels are found to be increased in many rheumatological diseases as rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis and vasculitis. There are recent studies evaluating the role of IL-33 in the pathogenesis of BD. In this paper, the role of IL-33 in BD is summarized.
Keywords: Behçet's disease, cytokin, IL-1, IL-33
 
 
Reklam
 
   
RAED Dergisi / RAED Journal

Türkiye Romatoloji Derneği (TRD) yayın organıdır. Deomed Yayıncılık tarafından yayımlanmaktadır. / Official Publication of the Rheumatology Society of Turkey (TRD). Published by Deomed Publishing. Copyright © 2018, TRD.
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