Ulusal Romatoloji Dergisi / Journal of Turkish Society for Rheumatology
 
 
p-ISSN: 2651-2653
e-ISSN: 2651-2661
Editor-in-Chief
Haner Direskeneli
2019 Volume 11
 
 
Deomed Yayıncılık
 
 
 
Volume 11, Issue 1, June 2019
Page(s): 16-22
 
Clinical Research Article
Received: July 14, 2018; Accepted: July 25, 2018; Published online: June 10, 2019
doi:10.2399/raed.19.52714; Copyright © 2019 Turkish Society for Rheumatology
Clinical distribution of antinuclear antibody (ANA) requests and positivity in daily practice: which departments request ANA test most frequently?
Döndü Üsküdar Cansu1 (E-mail), Hava Üsküdar Teke2, Eren Gündüz2, Cengiz Korkmaz1
1Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey; 2Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey
Summary
Objective: In this study, our primary aim was to determine the order frequency of antinuclear antibody (ANA) test according to special departments and its results in a university-based hospital. The second aim was to determine the most common cause of ANA test orders and to highlight the importance of "choosing wisely".

Methods: The frequency and results of ANA tests ordered for various reasons by clinicians between January 2014 and August 2016 were retrospectively screened by using ANA test code. ANA test was evaluated by indirect immunofluorescence test (IIF) method and reported as+1 positive, +2 positive, +3 positive, +4 positive according to fluorescent grade.

Results: 11,407 of ANA test results were taken into consideration. The first five department requiring the most ANA test was neurology, dermatology, rheumatology, pediatric nephrology and hematology. The rate of ANA positivity according to departments including neurology, dermatology, rheumatology and hematology was 14.9%, 15.4%, 32.6% and 14.1%, respectively. It was determined that the rate of +4 positivity of ANA test was the most in patients ordered by rheumatology department. (135/262=%51.5) (p<0.0001). The most reasons for ANA test according to ICD codes were headache, cerebrovascular events and multiple sclerosis for neurology department; urticaria, psoriasis and dermatitis for dermatology; systemic lupus erythematosus (SLE), arthritis, arthralgia, and fibromyalgia for rheumatology; anemia and thrombocytopenia for hematology.

Conclusion: Although neurology was the department that most frequently ordered ANA test in daily clinical practice in our hospital, negativity rate of ANA test was also high in neurology department. The rate of high positivity of ANA test was found by rheumatology department. As a result, in terms of "choosing wisely", when and in which patients ANA test be required must be well known. Awareness must be raised through information sharing on ANA test in order to avoid inappropriate ANA test request.
Keywords: Antinuclear antibody, indirect immunofluorescence test, rheumatology, choosing wisely
 
 
Reklam
 
   
RAED Dergisi / RAED Journal

Türkiye Romatoloji Derneği (TRD) yayın organıdır. Deomed Yayıncılık tarafından yayımlanmaktadır. / Official Publication of the Rheumatology Society of Turkey (TRD). Published by Deomed Publishing. Copyright © 2019, TRD.
Creative Commons License
RAED Dergisi çevrimiçi (online) sürümünde yayımlanan akademik içeriğin kullanım hakları, ilgili içerikte tersi belirtilmediği sürece Deomed Yayıncılık tarafından Creative Commons Attribution-NoCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) lisansı aracılığıyla bedelsiz sunulmaktadır. / Except where otherwise noted, academic content of this online version of the journal by Deomed Publishing is licensed under the terms of Creative Commons Attribution-NoCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND3.0) License.