Öz
The importance of enthesitis in the pathogenesis of spondyloarthritis (SpA) has been known since the 80s. The main reason for the differentiation of the clinical features of SpA from other inflammatory rheumatic diseases such as rheumatoid arthritis (RA) is the presence of enthesitis, and radiological studies show that the inflammation in SpA starts with enthesitis and there is a transition to synovitis. Recently, due to the recurrent microtraumas caused by mechanical factors in the enthesis region, enthesitis, and thereby new bone formation in individuals with an appropriate genetic background such as ankylosing spondylitis (AS), psoriatic arthritis (PsA), and enteropathic arthritis (EA) has been reported. Diagnosis of enthesitis is important in the differential diagnosis of inflammatory rheumatic diseases as well as in its treatment. The development of new therapeutic agents such as anti-IL-17, IL-12/23, and JAKi that are effective in enthesis requires an update of the SpA therapy.
Anahtar Kelimeler: Spondyloarthritis, enthesitis, therapy, IL-17, IL-12/23, JAKi
Kaynakça
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