Öz
Amaç:
Secukinumab, interlökin-17A’ya bağlanan insan immünoglobülin G1 kappa monoklonal antikorudur. Secukinumab kullanan aksiyal spondiloartrit (aksSpA) hastalarının demografik, klinik ve laboratuvar özelliklerini ve ilaç uyumunu ve ilaç yan etkilerini değerlendirmeyi amaçladık.
Yöntem:
Mayıs 2018-Mart 2022 tarihleri arasında merkezimize başvuran secukinumab ile tedavi edilen aksSpa’lı hastaların retrospektif analizi yapılmıştır.
Bulgular:
Elli iki hastanın, 20’si (%38,5) erkek idi. Ortalama aksiyel spondiloartrit tanı yaşı 36,5±12,1 idi. Ortalama takip süresi 89,3 (Q1-Q3: 65,0-160,9) ay idi. Hastaların 16’sı (%30,8) tümör nekroz faktörü-α (TNF-α) ihibitörü (TNFi) kullanmamıştı. On ikinci ve 24. ayda gözlemlenen secukinumab ilacı sağkalım oranları sırasıyla %96 ve %93 idi. İlaç kalma süresi, TNFi-naif ve TNFi yanıtsız (TNF-IR) grupları arasında anlamlı bir fark göstermedi (p=0,18). Secukinumab tedavisine başlandıktan sonra sadece 1 hasta ilk kez üveit atağı geçirdi. enflamatuvar barsak hastalığı alevlenmesi görülmedi.
Sonuç:
Çalışmamız Türkiye’den secukinumabın gerçek yaşam deneyimini sunmaktadır. TNFi-naif ve TNF-IR hastalarda tedavi yanıtının değişmemesi, secukinumabın hem TNFi-naif hem de TNF-IR hastalarında neredeyse eşit derecede etkili olduğunu göstermektedir. Sonuç olarak secukinumab, aksSpA’lı hastalar için güvenli ve etkili bir tedavi seçeneği olacaktır.
Anahtar Kelimeler: Sekukinumab, aksiyel spondiloartrit, IL-17A antikoru
Kaynakça
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