Öz
Amaç
Gut, kristal artropatinin en yaygın şeklidir ve eklemlerde monosodyum ürat kristallerinin birikmesinden kaynaklanır. Bu çalışmanın amacı, gut artropatisi olan hastalarda atak veya ataksız dönemde tiyol-disülfit dengesini araştırmaktır.
Yöntem
Gut hastalarında ve yaş-cinsiyet eşleştirilmiş sağlıklı kontrol grubunda doğal tiyol (DT) ve disülfit seviyelerini ölçmek için yeni geliştirilen bir spektrofotometrik yöntem kullanıldı. Toplam 90 gut hastası ve 86 sağlıklı kontrol incelendi. Klinik ve laboratuvar verileri tıbbi kayıtlardan elde edildi.
Bulgular
Gut hastalarında DT (p<0,001) ve toplam tiyol (TT) (p<0,001) seviyeleri sağlıklı kontrollere kıyasla anlamlı derecede düşüktü. Gut hastalarında atak ve ataksız dönemlerle DT ve TT düzeyleri arasında anlamlı bir fark yoktu (p>0,05).
Sonuç
Tiyol-disülfit homeostazisi gut hastalarında değişmekte, ancak atak döneminden etkilenmemektedir.
Anahtar Kelimeler: Gut, tiyol, disülfit, oksidan stres, tiyol-disülfit homeostazı
Kaynakça
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