Öz
Amaç
Ankilozan spondilit tanısı almış hastalarda uyku bozuklukları sıklıkla bel ağrısı, depresyon, kronik hastalıklar ve anksiyete ile ilişkilidir. Bu çalışma, uyku kalitesi ile hastalık aktivitesi ve fonksiyonel skorlar arasındaki korelasyonları analiz etmeyi amaçlamıştır.
Yöntem
Bu çalışmada, Ankara Üniversitesi Tıp Fakültesi, Romatoloji Polikliniği’ne başvuran 143 ankilozan spondilit hastası ve 143 sağlıklı gönüllüye Pittsburgh uyku kalitesi indeksi (PUKİ) uygulanmıştır. Hastalık aktivitesi Bath ankilozan spondilit hastalık aktivite indeksi (BASDAI) ile, fonksiyonel durum Bath ankilozan spondilit fonksiyonel indeksi (BASFI) ile değerlendirilmiş; C-reaktif protein düzeyleri hasta dosyalarından elde edilmiştir.
Bulgular
Yaş ve cinsiyet açısından hasta ve kontrol grupları arasında anlamlı fark saptanmamıştır. Ancak, kontrol grubu; öznel uyku kalitesi, uykuya dalma süresi, uyku bozukluğu, gündüz işlevselliği ve toplam PUKİ skorları açısından anlamlı derecede daha iyi sonuçlar göstermiştir. Hasta grubunda PUKİ skorları ile BASDAI, BASFI ve C-reaktif protein düzeyleri arasında anlamlı pozitif korelasyon saptanmıştır. Bu durum, artan hastalık aktivitesi, azalan fonksiyonel kapasite ve yükselen enflamasyonun kötüleşmiş uyku kalitesi ile ilişkili olduğunu göstermektedir.
Sonuç
Elde edilen veriler, uyku bozukluklarının hastalık aktivitesi ve diğer klinik parametrelerle doğrudan ilişkili olduğunu ortaya koymaktadır. Özellikle, anti-tümör nekroz faktörü tedavisi alan hastalarda uyku bozukluklarının daha düşük oranda görüldüğü gözlemlenmiştir.
Anahtar Kelimeler: Ankilozan spondilit, uyku bozuklukları, PUKİ, hastalık aktivitesi, anti-TNF
Kaynakça
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