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E-ISSN: 2651-2661 ISSN: 2651-2653
Sample size determination and power analysis in clinical trials
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Review
VOLUME: 3 ISSUE: 2
P: 29-33
June 2011

Sample size determination and power analysis in clinical trials

J Turk Soc Rheumatol 2011;3(2):29-33
DOI: 10.2399/raed.11.005
Necdet Süt
1. Trakya Üniversitesi Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Edirne
No information available.
No information available
Received Date: 18.01.2011
Accepted Date: 31.01.2011
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ABSTRACT

The aim of this review is to: i) stress the effect of sample size and power analysis on study results, ii) construct information to guide researchers on the components that should be taken into consideration in order to calculate the sample size. The components which effect sample size calculation with power analysis in clinical trials are type I error (α), type II error (β), difference between the groups or effect size, allocation ratio and direction of study hypothesis (one/two sided). Sample size calculation with power analysis in the planning stage of clinical trials guarantees the reliability of the study results, in addition to preventing source extravagance.