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Evaluation of serum pregnancy associated plasma protein-A levels in patients with rheumatoid arthritis
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Original Article
VOLUME: 12 ISSUE: 2
P: 45-50
August 2020

Evaluation of serum pregnancy associated plasma protein-A levels in patients with rheumatoid arthritis

J Turk Soc Rheumatol 2020;12(2):45-50
DOI: 10.4274/raed.galenos.2020.29291
Murat Torgutalp 1
Özlem Ceylan Doğan 2
Müçteba Enes Yayla 1
Didem Şahin Eroğlu 1
Ayşe Bahar Keleşoğlu Dinçer 1
Serdar Sezer 1
Emine Gözde Aydemir Gülöksüz 1
Tahsin Murat Turgay 1
Gülay Kınıklı 1
Aşkın Ateş 1
1. Ankara Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, Ankara, Türkiye
2. Ankara Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye
No information available.
No information available
Received Date: 28.06.2020
Accepted Date: 17.07.2020
Publish Date: 27.08.2020
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ABSTRACT

Conclusion:

In conclusion, PAPP-A levels were higher in patients with RA in comparison to controls, but there was no significant correlation with disease activity. Pathophysiological pathways of increased PAPP-A in RA are unclear. Further studies are required to better elucidate the role of PAPP-A level in RA, especially in patients who have concomitant CAD.

Results:

The serum PAPP-A levels of the RA patients were significantly higher than those of healthy controls (0.53±0.17 mIU/L, 0.43±0.15 mIU/L, respectively; p=0.003). Distribution of age and gender between these groups were similar. We found no statistically significant difference between group 1 (n=26) and group 2 (n=29) in PAPP-A levels, 0.53±0.16 and 0.52±0.17 respectively. p=0.88. And also, the data showed no statistically significant relationship between serum PAPP-A levels and disease activity parameters.

Methods:

A total of 55 RA patients underwent to clinical (disease activity score-DAS28), laboratory [erythrocyte sedimentation rate (ESR), C-reactive protein], and ultrasound examinations. RA patients were divided into two subgroups according to their DAS28-ESR; group 1 (DAS-28<3.2), group 2 (DAS28≥3.2), respectively. Forty-four healthy controls were simultaneously studied.

Objective:

Rheumatoid arthritis (RA) is a systemic disorder characterized by inflammatory arthritis. Coronary artery diseases (CADs) are important reason for mortality in RA. Pregnancy-associated plasma protein-A (PAPP-A) is independently related to cardiovascular events in patients with CAD and it could be a sensitive biomarker of disease activity in inflammatory diseases. In this study, we aimed to measure serum PAPP-A level and assess the association with disease activity parameters in patients with RA.

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