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E-ISSN: 2651-2661 ISSN: 2651-2653
Fetuin-A and its association with disease activity in psoriatic arteritis
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Original Article
VOLUME: 13 ISSUE: 2
P: 47-53
August 2021

Fetuin-A and its association with disease activity in psoriatic arteritis

J Turk Soc Rheumatol 2021;13(2):47-53
DOI: 10.4274/raed.galenos.2021.24865
Semih Gülle 1
Sevgi Öztürk 2
Leyla Didem Kozacı 3
Murat Keser 4
Pınar Çetin 5
Necati Günay 6
Fatoş Önen 1
İsmail Sarı 1
1. Dokuz Eylül Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, İzmir, Türkiye
2. Bergama Devlet Hastanesi, Dahiliye Kliniği, İzmir, Türkiye
3. Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye
4. Sağlık Bilimleri Üniversitesi, İzmir Tepecik Eğitim ve Araştırma Hastanesi, Tıbbi Onkoloji Kliniği Dalı, İzmir, Türkiye
5. Yunus Emre Devlet Hastanesi, Romatoloji Kliniği, Eskişehir, Türkiye
6. Bilim ve Teknoloji Araştırma ve Uygulama Merkezi (ADU-Bİ-LTEM), Adnan Menderes Üniversitesi, Aydın, Türkiye
No information available.
No information available
Received Date: 13.02.2021
Accepted Date: 08.04.2021
Publish Date: 31.08.2021
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ABSTRACT

Objective:

Psoriatic arthritis (PsA) is one of the spondyloarthropathies associated with psoriasis. Recent data suggest an increased prevalence of cardiovascular disease in patients with PsA, similar to that observed in psoriasis. Fetuin-A is a novel biomarker related to vascular calcification and atherosclerosis. In this study, we aimed to investigate the association between fetuin-A concentrations and PsA-related parameters.

Methods:

Ninety-seven non-diabetic PsA patients who fulfilled the CASPAR criteria and 57 age- and sex-matched healthy controls were included. Disease activity was assessed by using CPDAI, BASDAI, DAS28-CRP and PASI. Serum lipids, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and fetuin-A were studied.

Results:

There were 97 PsA patients [48 (min-max: 25-65) years, 32M/65F] and 57 healthy subjects [43 (min-max: 31-57) years, 24M/33F]. Disease duration of the PsA patients was 4 (min-max: 0-43) years. Distributions of age, sex, and body mass index were similar between the groups. Fetuin-A concentrations were significantly lower in the patients than in controls (p<0.001). When the PsA group was divided into peripheral (n=14), axial (n=52) and both peripheral and axial subgroups (n=31), fetuin A remained significantly lower in the each group compared to controls (p<0.001). There were negative correlations between fetuin-A concentrations and CPDAI, PASI, hs-CRP and ESR (r=-0.26, r=-0.25, r=-0.3, and r=-0.26, respectively; p<0.05).

Conclusion: Fetuin-A was lower in the PsA group than in healthy controls, regardless of disease subgroups. The negative relationship of this marker with acute phase reactants and disease activity indices suggests that reduced fetuin-A levels are associated with disease-related factors.

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