ABSTRACT

The serum level of HDL cholesterol (HDL-C) and ApoA1 are decreased in patients with familial Mediterraen fever. The objective of this study was to assess influence of MEFV variations on serum lipid profile.

The 8864 MEFV variations were assessed between July 1999 to August 2008, retrospectively. The age, sex, erythrocyte sedimentation rate, C-reactive protein, leukocyte, fibrinogen, HDL-C, LDL-C, TC and triglyceride levels were noted. The people were classified according to inflammation status as either "non-inflammatory group" or "inflammatory group". All patients were screened for 10 common MEFV variations.

Seven hundred forty eight people (57% female) were appropriate for the assessment. The mean age was 36±12 SD years. Five hundred twenty one people (69.5%) were in ''non-inflammatory group''. In the non-inflammatory group, MEFV negative people had higher HDL-C levels compared to MEFV homozygote or compound heterozygote [58.9±17.9 vs 50.7±14.5, p<0.001] people. MEFV negative people also had high HDL-C [58.9±17.9 vs 54.5±13.3, p=0.024], and TC levels [108.6±80.5 vs 116.7±76.9, p=0.037] than MEFV heterozygote people. M694V homozygote people had more prominent dyslipidemic lipid profile; mean serum HDL-C level was 45.1±12.6 mg/dl.

The MEFV homozygote, compound heterozygote or heterozygote people had low HDL-C, LDL-C and TC serum levels compared to MEFV negative people. MEFV variations may be one of the reasons of low serum HDL-C levels in the Turkish population.